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“Cardiopulmonary Interactions” with IHLH Researchers

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On April 27th, three researchers from the IHLH will be speaking at the Canadian Respiratory Conference in a session entitled “Cardiopulmonary Interactions”. This is a great opportunity for them to showcase their research and to update the public and other medical professionals what is happening within the IHLH!

 

COPD is Really a Heart Disease

From writing notes in his lab, to speaking to Global BC audiences, Dr. Don Sin is not only a talented scientist, but also a true communicator of science. He speaks with clarity and concern about COPD, and is an advocate for all patients as he works to establish that COPD is really a heart disease. In this presentation, the audience will learn the close relationship between COPD and cardiovascular disease from epidemiology to mechanisms. The audience will also learn of the importance of lung inflammation and injury in effecting this process and the molecules and mediators that are critical in these pathways. A discussion of ways of exploiting this new knowledge in developing novel targets for therapeutics and biomarkers in COPD will also be presented.

 

 

 

 

Cardiopulmonary Physiology: Implication for Health and Disease

As practicing Intensivist at St. Paul’s Hospital ICU and investigator at the University of British Columbia Heart + Lung Institute laboratories since 1988, Dr. Keith Walley is dedicated to connecting research with practice. In this session, pathophysiology will be directly related to clinical problems. The key ways that pulmonary airway pressures influence cardiac output will be reviewed (hypotension at the time of intubation, PPV to diagnose hypovolemia, PEEP for the hypervolemic failing heart). Then, the influence of pulmonary vascular resistance on right heart function, and consequently left heart function, will be addressed (pulmonary hypertension, pulmonary embolism). The influence of cardiovascular hyper- and hypo-volemia on lung gas exchange will also be addressed (hypoxemia due to pulmonary edema and high dead space, respectively). Finally, the role of cardiovascular interventions in managing severe hypoxemia will be discussed (severe hypoxemia).

 

 

 

Air Pollution: Impact on the Lungs and the Cardiovascular System

Dr. Stephan van Eeden will shed new light on the topic of Air Pollution in his presentation by discussing the injurious effects of ambient pollutants, in particular, particulate matter (PM). PM and other such ambient pollutants are local (in the lung) or systemic, with downstream effects on other organ systems, in particular the cardiovascular system. Air pollution-induced respiratory morbidity and mortality are related to admissions for pneumonia, asthma, pulmonary embolism and chronic obstructive pulmonary disease. Of all the pollutants, PM shows the strongest association with adverse respiratory health effects even when adjusted for the other major risk factors such as cigarette smoking. The association between exposure to PM and cardiovascular morbidity and mortality is also well established and it has been shown that exposure to PM has adverse cardiovascular health effects by triggering ischemic heart diseases and cardiac arrhythmias. Mechanistic studies support the hypothesis that inhalation of PM causes inflammation in the airways and lungs but also induces a systemic inflammatory response (that impacts on coronary arteries, resulting in adverse cardiovascular events) and cerebrovascular effects causing stroke.